• Clinical trials in restless legs syndrome - Recommendations of the European RLS study group (EURLSSG) 

      Trenkwalder, C.; Kohnen, R.; Allen, R. P.; Benes, H.; Ferini-Strambi, L.; Garcia-Borreguero, D.; Hadjigeorgiou, G. M.; Happe, S.; Hogl, B.; Hornyak, M.; Klein, C.; Nass, A.; Montagna, P.; Oertel, W. H.; O'Keeffe, S.; Paulus, W.; Poewe, W.; Provini, F.; Pramstaller, P. P.; Sieminski, M.; Sonka, K.; Stiasny-Kolster, K.; de Weerd, A.; Wetter, T. C.; Winkelmann, J.; Zucconi, M. (2007)
      The European Restless Leas Syndrome (RLS) Study Group (EURLSSG) is an association of European RLS experts who are actively involved in RLS research. A major aim of the Study Group is the development and continuous improvement ...
    • Family-based association study of the loci 2 and 3 in a European restless legs syndrome population 

      Kemlink, D.; Polo, O.; Montagna, P.; Provini, F.; Stiasny-Kolster, K.; Oertel, W.; de Weerd, A.; Nevsimalova, S.; Sonka, K.; Hogl, B.; Frauscher, B.; Poewe, W.; Trenkwalder, C.; Pramstaller, P. P.; Ferini-Strambi, L.; Zucconi, M.; Konofal, E.; Arnulf, I.; Hadjigeorgiou, G. M.; Happe, S.; Klein, C.; Hiller, A.; Lichtner, P.; Meitinger, T.; Muller-Myshok, B.; Winkelmann, J. (2007)
      Three loci for the restless legs syndrome (RLS) on chromosomes 12q, 14q, and 9p (RLS 1, RLS2, and RLS3) have been mapped, but no gene has been identified as yet. RLS1 has been confirmed in families from three different ...
    • Genetics of restless legs syndrome (RLS): State-of-the-art and future directions 

      Winkelmann, J.; Polo, O.; Provini, F.; Nevsimalova, S.; Kemlink, D.; Sonka, K.; Hogl, B.; Poewe, W.; Stiasny-Kolster, K.; Oertel, W.; de Weerd, A.; Strambi, L. F.; Zucconi, M.; Pramstaller, P. P.; Arnulf, I.; Trenkwalder, C.; Klein, C.; Hadjigeorgiou, G. M.; Happe, S.; Rye, D.; Montagna, P. (2007)
      Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no ...
    • Progressive development of augmentation during long-term treatment with levodopa in restless legs syndrome: results of a prospective multi-center study 

      Hogl, B.; Garcia-Borreguero, D.; Kohnen, R.; Ferini-Strambi, L.; Hadjigeorgiou, G.; Hornyak, M.; de Weerd, A.; Happe, S.; Stiasny-Kolster, K.; Gschliesser, V.; Egatz, R.; Frauscher, B.; Benes, H.; Trenkwalder, C.; Hening, W. A.; Allen, R. P. (2010)
      The European Restless Legs Syndrome (RLS) Study Group performed the first multi-center, long-term study systematically evaluating RLS augmentation under levodopa treatment. This prospective, open-label 6-month study was ...
    • Validation of the Augmentation Severity Rating Scale (ASRS): A multicentric, prospective study with levodopa on restless legs syndrome 

      García-Borreguero, D.; Kohnen, R.; Högl, B.; Ferini-Strambi, L.; Hadjigeorgiou, G. M.; Hornyak, M.; de Weerd, A. W.; Happe, S.; Stiasny-Kolster, K.; Gschliesser, V.; Egatz, R.; Cabrero, B.; Frauscher, B.; Trenkwalder, C.; Hening, W. A.; Allen, R. P. (2007)
      Background: Augmentation is the main complication during long-term dopaminergic treatment of restless legs syndrome (RLS) and reflects an overall increase in RLS severity. Its severity varies considerably from a minor ...